Abnormal B Lymphocyte Activation and Function in Systemic Sclerosis
نویسندگان
چکیده
منابع مشابه
Abnormal B Lymphocyte Activation and Function in Systemic Sclerosis
Systemic sclerosis (SSc) is characterized by tissue fibrosis and autoimmunity. Although the pathogenic relationship between autoimmunity and clinical manifestations of SSc remains unknown, SSc patients display abnormal immune responses including the production of disease-specific autoantibodies. Previous studies have demonstrated that B cells play a critical role in systemic autoimmunity and di...
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BACKGROUND Previous reports on lymphocyte subpopulations in systemic sclerosis (SSc) are conflicting. Therefore, we aimed to investigate the lymphocyte subsets in SSc patients who were not on immunosuppressive therapy. METHODS Lymphocyte subsets were assessed in the peripheral blood of SSc patients (n = 29) and healthy controls (n = 29) using the four colour flow cytometry method. Correlation...
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OBJECTIVE To investigate interactions of immune cells with vascular endothelium in patients with systemic sclerosis (SSc) and in patients with idiopathic or autoimmune Raynaud's phenomenon (RP). METHODS Lymphocytes obtained from 11 patients with SSc, 9 with RP and 14 control subjects were pre-stimulated in vitro with alloantigens and cultured together with human umbilical vein endothelial cel...
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A substantial heterogeneity exists in the amount of immunoglobulin (Ig) on the surface of bone marrow-derived (B) lymphocytes as measured by labeling these cells with fluorescein-conjugated (F1) 1 anti-Ig and analyzing them by the technique of rapid flow microfluorometry (RFMF). Ig-bearing lymphocytes from neonatal mouse spleen and from adult mouse bone marrow are very diverse populations when ...
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ژورنال
عنوان ژورنال: Annals of Dermatology
سال: 2015
ISSN: 1013-9087,2005-3894
DOI: 10.5021/ad.2015.27.1.1